Entering the 2022 season:
| Rank | School (No. 1 votes) | W-L | Points |
| 1 | Mary Hardin-Baylor (23) | 15-0 | 619 |
| 2 | North Central (Ill.) | 13-1 | 587 |
| 3 | Mount Union (2) | 13-1 | 577 |
| 4 | UW-Whitewater | 13-1 | 537 |
| 5 | St. John's | 11-1 | 480 |
| 6 | Hardin-Simmons | 9-1 | 451 |
| 7 | Linfield | 11-1 | 445 |
| 8 | Wheaton (Ill.) | 10-2 | 419 |
| 9 | Trinity (Texas) | 9-1 | 378 |
| 10 | Johns Hopkins | 10-2 | 358 |
| 11 | Muhlenberg | 11-2 | 326 |
| 12 | UW-La Crosse | 9-3 | 314 |
| 13 | Bethel | 8-3 | 310 |
| 14 | Central | 12-1 | 287 |
| 15 | Delaware Valley | 11-1 | 262 |
| 16 | Cortland | 11-1 | 211 |
| 17 | Ithaca | 8-2 | 183 |
| 18 | UW-River Falls | 9-2 | 180 |
| 19 | UW-Oshkosh | 6-3 | 156 |
| 20 | RPI | 11-2 | 130 |
| 21 | Randolph-Macon | 9-1 | 121 |
| 22 | Salisbury | 8-2 | 120 |
| 23 | Hobart | 9-2 | 94 |
| 24 | Heidelberg | 7-2 | 81 |
| 25 | Birmingham-Southern | 10-2 | 67 |
Others receiving votes: Susquehanna 59; Carnegie Mellon 55; Baldwin Wallace 52; Redlands 49; John Carroll 39; Union 36; Lake Forest 31; Aurora 27; Westminster (Pa.) 24; Claremont-Mudd-Scripps 10; Wartburg 7; Gustavus Adolphus 6; Albion 6; DePauw 6; UW-Stout 4; Washington U. 4; Washington & Jefferson 4; Centre 3; Rose-Hulman 3; Huntingdon 2; Williams 2; Coe 1; Grove City 1; Washington and Lee 1.
The D3football.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.